Shares of bluebird bio, Inc. (NASDAQ:BLUE) has price volatility of 8.62% in last 5 days trading session, as shares of firm closed at $60.35 by moving down of -6.29% in last session. Shares price moving up from its 20 days moving average with 7.93% and isolated positively from 50 days moving average with 0.13%. Bluebirdbio reported interim Phase 1 dose escalation data for Anti-BCMA CAR T product candidate in patients with relapsed/refractory multiple myeloma; 100% of patients in second and third dose cohorts achieved objective response; two patients MRD-negative; overall response rate 78% (BLUE).
Patients on study were heavily pre-treated, with a median of six previous therapies (range: 5 – 13). As of the November 18th, 2016 data cut-off, 11 patients had been enrolled and dosed in four dose cohorts: 5.0 x 107, 15.0 x 107, 45.0 x 107 and 80 x 107 CAR+ T cells. All 11 dosed patients were evaluable for safety, and the first nine patients (5.0 x 107, 15.0 x 107, 45.0 x 107 dose cohorts) have undergone their first multiple myeloma tumor restaging and were evaluable for efficacy. This study is presently enrolling patients at seven sites in the U.S., with an anticipated total enrollment of 50 patients. Patients attained a conditioning regimen of cyclophosphamide and fludarabine, followed by an infusion of bb2121 anti-BCMA CAR T cells. The CAR T cells were produced from each patient’s own blood cells, which were modified using a lentiviral vector encoding the anti-BCMA CAR.
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Shares of Spirit AeroSystems Holdings, Inc. (NYSE:SPR) swings by following news as it reduced -0.65% to $58.25 in recent trading flood. Spirit Aerosystems (SPR) completed Spirit Wichita expansion project to support production rate raises already planned for the Boeing (BA) 737. (Spirit is responsible for delivering about 70 percent of the 737 structure to Boeing).
Spirit AeroSystems Inc. (NYSE:SPR) released that completion of an expansion project on the Spirit Wichita campus to support production of the 737 thrust reverser. The expansion supports production rate raises already planned for the Boeing 737 program. The firm also celebrated delivering the first 737 MAX thrust reverser with the new composite inner wall to the flight test program. Spirit produces the 737 MAX fuselage, pylon, thrust reverser and engine nacelle at its Wichita, Kan., facility and the wing leading edges at its Tulsa, Okla., facility. Spirit is responsible for delivering about 70 percent of the 737 structure to Boeing. The return on equity was 24.80%. The firm’s Debt to equity ratio was 0.61.
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United Technologies Corporation (NYSE:UTX) collapsed -1.03% to finish at $107.72 in following trading session. United Tech’s (UTX) Carrier confirms had ‘very productive’ conversations in recent days with President-elect Trump and Vice President-elect Pence (see 6:46 comment).
“We have negotiated an contract with the incoming administration that we believe benefits our workers, the state of Indiana and our firm. We are announcing that Carrier will continue to manufacture gas furnaces in Indianapolis, in addition to retaining engineering and headquarters staff, preserving over 1,000 jobs.” The incentives provided by the state were an important consideration. The corporation has return on equity of 25.70% and while returns on assets was calculated 8.20% with 15.11% year to date performance. The yearly sales growth for the past five year was 1.40%.
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