The Medicines Company (NASDAQ:MDCO) luring passive investments, as shares knock down -7.99% ended at $48.38 as the stock held volume of 20.5 Million as compared to average daily volume of 1467.25. The Medicines Co (MDCO) and Alnylam Pharmaceuticals (ALNY) announce positive final results from the ORION-1 Phase II study of inclisiran. Inclisiran demonstrated important and sustained reductions in LDL-C and high standards of safety and tolerability.
Optimal starting dose regimen (300 mg injection administered on Day-1 and Day-90) lowered LDL-C by average of 52.6% (64 mg/dL) and up to 81% (122 mg/dL) at Day-180, and by time-adjusted mean of >50% (63 mg/dL) for the six-month period from Day-90 through Day-270; every patient displayed important response and mean LDL-C reductions over this time period were practically constant. Robust ORION-1 data reaffirm inclisiran’s potential to address unmet needs with highly-differentiated, infrequent, low-volume dosing regimen of two or three injections per year.
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Bristol-Myers Squibb Company (NYSE:BMY) moves down -1.78% to close at $56.29 with the total traded volume of 15.88 Million. The firm’s current ratio calculated as 1.60 for the most recent quarter Bristol-Myers (BMY) and Pfizer (PFE) present findings from a real-world data analysis of the U.S. Medicare database comparing the risk of stroke or systemic embolism and rate of major bleeding among patients with non-valvular atrial fibrillation who were treated with direct oral anticoagulants versus warfarin.
In this observational analysis, medical and pharmacy claims were evaluated from the U.S. Medicare fee-for-service database of non-valvular atrial fibrillation patients age 65 and older who were newly prescribed oral anticoagulation therapy between January 1, 2013, and December 31, 2014 (n=186,132, following inclusion and exclusion criteria).Eliquis, in this analysis, was associated with a importantly lower risk of stroke or systemic embolism (HR: 0.40, 95% CI: 0.31-0.53; p<0.0001) and lower rate of major bleeding (HR: 0.51, 95% CI: 0.44-0.58; p<0.0001) than patients treated with warfarin. The findings from the Eliquis-warfarin cohort complement the results of the randomized Phase 3 ARISTOTLE (Apixaban for Reduction In Stroke and Other ThromboemboLic Events in Atrial Fibrillation) trial
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Stocks of Zosano Pharma Corporation (NASDAQ:ZSAN) shows active performance, collapsed -9.88% to trade at $1.55as ZosanoPharma (ZSAN) declared that prices 17,000,000 share offering at $1.50 per share. Zosano intends to use the net proceeds of the proposed offering to fund the manufacture of its lead product candidate, M207, in sufficient quantities to support its long term safety study and associated regulatory activities necessary to file for product approval, and to fund a portion of the long term safety study itself.
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